Knocking down Goliath

Knocking down glycosaminoglycan synthesis.

Knocking down Disease with siRNAs

Knocking down expression of disease-related genes using small interfering RNAs (siRNAs) has potential for treating a variety of illnesses. This Essay will examine the opportunities for harnessing RNA interference (RNAi) for therapy, as well as the obstacles and possible ways to circumvent them.

Knocking down the obstacles to functional genomics data sharing

This week, Scientific Data published a collection of eight papers that describe datasets from high-throughput functional genomics screens, primarily utilizing RNA interference (RNAi). The publications explore host-pathogen dependencies, innate immune response, disease pathways, and cell morphology and motility at the genome-level. All data, including raw images from the high content screens, ar...

Knocking down your organization's barriers to efficiency and effectiveness.

The money for digitization and comparative effectiveness research in the ARRA (“stimulus”) Act, plus this year’s reform effort and its sequelae together bring us a distinct and powerful challenge: How do we bring health care to people better, faster, cheaper? And any good results of that push in the U.S. will show up in other national health care economies. Since the U.S. pays more and in many ...

Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish

Purpose. The small nuclear ribonucleoprotein 200 kDa (SNRNP200) gene is a fundamental component for precursor message RNA (pre-mRNA) splicing and has been implicated in the etiology of autosomal dominant retinitis pigmentosa (adRP). This study aims to determine the consequences of knocking down Snrnp200 in zebrafish. Methods. Expression of the Snrnp200 transcript in zebrafish was determined via...